Chlorpheniramine is an antihistamine. It blocks the effects of the naturally occurring
chemical histamine in the body. Chlorpheniramine prevents sneezing; itchy, watery eyes and
nose; and other symptoms of allergies and hay fever.
Phenylpropanolamine is a decongestant. It constricts (shrinks) blood vessels (veins and
arteries). This reduces the blood flow to certain areas and allows nasal passages to open up.
Chlorpheniramine and phenylpropanolamine is used to treat nasal congestion and sinusitis
(inflammation of the sinuses) associated with allergies, hay fever, and the common cold.
Phenylpropanolamine, an ingredient in this product, has been associated with an increased
risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in
women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food
and Drug Administration (FDA) recommends that consumers not use any products that contain
phenylpropanolamine.
Chlorpheniramine and phenylpropanolamine may also be used for purposes other than
those listed in this medication guide.
Take chlorpheniramine and phenylpropanolamine exactly as directed. If you do not
understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.
Do not crush, chew, or break the long-acting or sustained-release forms of this
medication. Swallow them whole. If you are unsure of the formulation of your medicine, ask
your pharmacist for help.
If you cannot swallow the tablets or capsules, look for a liquid form of the medication.
To ensure that you get a correct dose, measure the liquid forms of chlorpheniramine and
phenylpropanolamine with a special dose-measuring spoon or cup, not with a regular table
spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Do not take more of this medication than is recommended. An overdose of this
medication can cause serious harm.
Do not take chlorpheniramine and phenylpropanolamine for longer than 7 days in a row.
If your symptoms do not improve, if they get worse, or if you have a fever, talk to your doctor.
Store chlorpheniramine and phenylpropanolamine at room temperature away from
moisture and heat.
Serious side effects are unlikely to occur. Stop taking chlorpheniramine and
phenylpropanolamine and seek emergency medical attention if you experience an allergic
reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or
hives).
Other, less serious side effects may be more likely to occur. Continue to take
chlorpheniramine and phenylpropanolamine and talk to your doctor or try another similar
medication if you experience
dryness of the eyes, nose, and mouth;
drowsiness or dizziness;
blurred vision;
difficulty urinating; or
excitation in children.
Side effects other than those listed here may also occur. Talk to your
doctor about any side effect that seems unusual or that is especially bothersome.
Do not take chlorpheniramine and phenylpropanolamine if you have taken a
monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or
tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading
to serious side effects.
Do not take other over-the-counter cough, cold, allergy, diet, or sleep aids while taking
chlorpheniramine and phenylpropanolamine without first talking to your doctor or pharmacist.
Other medications may also contain chlorpheniramine, phenylpropanolamine, or other similar
drugs. You may accidentally take too much of these medicines.
Chlorpheniramine and phenylpropanolamine may increase the effects of other drugs that
cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety
medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or
drowsiness may occur if chlorpheniramine and phenylpropanolamine is taken with any of these
medications.
Drugs other than those listed here may also interact with chlorpheniramine and
phenylpropanolamine. Talk to your doctor and pharmacist before taking any prescription or
over-the-counter medicines.
Use caution when driving, operating machinery, or performing other hazardous
activities. Chlorpheniramine and phenylpropanolamine may cause dizziness or drowsiness. If you
experience dizziness or drowsiness, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking
chlorpheniramine and phenylpropanolamine.
Chlorpheniramine and phenylpropanolamine may increase the effects of other drugs that
cause drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety
medicines, seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or
drowsiness may occur if chlorpheniramine and phenylpropanolamine is taken with any of these
medications.
Take the missed dose as soon as you remember. However, if it is almost time for the next
dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of this medication.
Phenylpropanolamine, an ingredient in this product, has been associated with an increased
risk of hemorrhagic stroke (bleeding into the brain or into tissue surrounding the brain) in
women. Men may also be at risk. Although the risk of hemorrhagic stroke is low, the U.S. Food
and Drug Administration (FDA) recommends that consumers not use any products that contain
phenylpropanolamine.
Use caution when driving, operating machinery, or performing other hazardous
activities. Chlorpheniramine and phenylpropanolamine may cause dizziness or drowsiness. If you
experience dizziness or drowsiness, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking
chlorpheniramine and phenylpropanolamine.
Do not take more of this medication than is recommended. If your symptoms do not
improve, or if they worsen, talk to your doctor.
Do not take chlorpheniramine and phenylpropanolamine if you have taken a
monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or
tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading
to serious side effects.
Before taking this medication, tell your doctor if you have
kidney disease,
liver disease,
diabetes,
glaucoma,
any type of heart disease or high blood pressure,
thyroid disease,
emphysema or chronic bronchitis, or
difficulty urinating or an enlarged prostate.
You may not be able to take chlorpheniramine and
phenylpropanolamine, or you may require a dosage adjustment or special monitoring during
treatment if you have any of the conditions listed above.
Chlorpheniramine and phenylpropanolamine is in the FDA pregnancy category B.
This means that it is unlikely to harm an unborn baby. Do not take this medication without first
talking to your doctor if you are pregnant.
This medication passes into breast milk and may harm a nursing baby. Do not take
this medication without first talking to your doctor if you are breast-feeding a baby.
If you are over 65 years of age, you may be more likely to experience side effects
from chlorpheniramine and phenylpropanolamine. You may require a lower dose of this
medication.
Read the package label for directions or consult your doctor or pharmacist before
treating a child with this medication. Children are more susceptible than adults to the effects of
medicines and may have unusual reactions.
Many formulations of chlorpheniramine and phenylpropanolamine are available both
over-the-counter and with a prescription. Ask your pharmacist any questions you have about this
medication, especially if it is new to you.
Remember, keep this and all other medicines out of the reach of children, never share
your medicines with others, and use this medication only for the indication prescribed.
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up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive.
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The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions,
or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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