Acetaminophen is a pain reliever and a fever reducer.
Diphenhydramine is an antihistamine. It blocks the effects of the naturally occurring chemical
histamine in the body. Diphenhydramine prevents sneezing; itchy, watery eyes and nose; and other
symptoms of allergies and hay fever.
Acetaminophen and diphenhydramine is used to treat watering of the eyes, congestion,
sneezing, and itchy throat caused by allergies and hay fever.
Acetaminophen and diphenhydramine may also be used for purposes other than those listed in
this medication guide.
Take acetaminophen an diphenhydramine exactly as directed by your doctor or follow the
instructions on the package label. If you do not understand these directions, ask your pharmacist, nurse,
or doctor to explain them to you.
Take each dose with a full glass of water.
Never take more acetaminophen and diphenhydramine than is directed. The maximum amount
of acetaminophen for adults is 1 gram (1000 mg) per dose and 4 grams (4000 mg) per day. Taking
more acetaminophen could cause damage to your liver. If you drink more than three alcoholic
beverages per day, talk to your doctor before taking acetaminophen and diphenhydramine and never
take more than 2 grams (2000 mg) per day.
Consult your doctor if your symptoms do not improve within 10 days (or 5 days for children
under 12 years of age) or if they get worse. Do not use this product to treat a fever for more than 3
days.
Store acetaminophen and diphenhydramine at room temperature away from moisture and
heat.
If you experience any of the following serious side effects, stop taking acetaminophen and
diphenhydramine and seek emergency medical attention:
an allergic reaction (difficulty breathing; closing of your throat;
swelling of your lips, tongue, or face; or hives);
liver damage (yellowing of the skin or eyes, nausea,
abdominal pain or discomfort, unusual bleeding or bruising, or severe fatigue);
blood problems (easy or unusual bleeding or bruising); or
low blood sugar (fatigue, increased hunger or thirst,
dizziness, or fainting).
Other, less serious side effects may be more likely to occur including:
dry eyes, nose, and mouth;
drowsiness or dizziness;
blurred vision;
difficulty urinating; or
excitation in children.
Side effects other than those listed here may also occur. Talk to your doctor
about any side effect that seems unusual or that is especially bothersome.
Do not take acetaminophen and diphenhydramine if you have taken a monoamine oxidase
inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in
the last 14 days. A very serious drug interaction could occur, leading to serious side effects.
Urine glucose tests for diabetics may produce false results while you are taking acetaminophen.
Talk to your doctor if you are diabetic and you notice changes in your glucose levels during therapy
with acetaminophen and diphenhydramine.
Do not take other over-the-counter cough, cold, allergy, diet, pain, or sleep medicines while
taking acetaminophen and diphenhydramine without first talking to your doctor or pharmacist. Other
medications may also contain acetaminophen, diphenhydramine, or other similar drugs, and you may
accidentally take too much of these medicines.
Acetaminophen and diphenhydramine may increase the effects of other drugs that cause
drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines,
seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if
acetaminophen and diphenhydramine is taken with any of these medications.
Drugs other than those listed here may also interact with acetaminophen and diphenhydramine.
Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.
Use caution when driving, operating machinery, or performing other hazardous activities.
Acetaminophen and diphenhydramine may cause dizziness or drowsiness. If you experience dizziness
or drowsiness, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking
acetaminophen and diphenhydramine. Also, alcohol is very damaging to your liver when it is taken with
acetaminophen.
Acetaminophen and diphenhydramine may increase the effects of other drugs that cause
drowsiness, including antidepressants, alcohol, other antihistamines, pain relievers, anxiety medicines,
seizure medicines, and muscle relaxants. Dangerous sedation, dizziness, or drowsiness may occur if
acetaminophen and diphenhydramine is taken with any of these medications.
Symptoms of an acetaminophen and diphenhydramine overdose may include nausea, vomiting,
diarrhea, abdominal pain, sweating, seizures, confusion, sedation, insomnia, tremor, hallucinations, and
an irregular heartbeat.
Take the missed dose as soon as you remember. However, if it is almost time for your next
dose, skip the missed dose and take only your next regularly scheduled dose. Do not
take a double dose of this medication.
Use caution when driving, operating machinery, or performing other hazardous activities.
Acetaminophen and diphenhydramine may cause dizziness or drowsiness. If you experience dizziness
or drowsiness, avoid these activities.
Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking
acetaminophen and diphenhydramine. Alcohol may also cause damage to your liver when taken with
acetaminophen.
Do not take acetaminophen and diphenhydramine without first talking to your doctor if you
drink more than three alcoholic beverages per day or if you have had alcoholic liver disease. You may
not be able to take acetaminophen.
Do not take acetaminophen and diphenhydramine if you have taken a monoamine oxidase
inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in
the last 14 days. A very serious drug interaction could occur, leading to serious side effects.
Before taking this medication, tell your doctor if you have
kidney disease;
liver disease;
diabetes;
glaucoma;
difficulty urinating because of an enlarged prostate, a
constricted bladder neck, or any other reason;
a stenosing peptic (stomach) ulcer;
high blood pressure or any type of heart disease; or
an overactive thyroid.
You may not be able to take acetaminophen and diphenhydramine, or you
may require a dosage adjustment or special monitoring during treatment if you have any of the
conditions listed above.
It is not known whether acetaminophen and diphenhydramine will harm an unborn baby.
Do not take acetaminophen and diphenhydramine without first talking to your doctor if you are
pregnant.
Acetaminophen and diphenhydramine passes into breast milk and can seriously harm a
nursing infant. Do not take this medication without first talking to your doctor if you are breast-feeding a
baby.
If you are over 60 years of age, you may be more likely to experience side effects from
acetaminophen and diphenhydramine.
Read the package label for directions or consult your doctor or pharmacist before treating a
child with this medication. Children are more susceptible than adults to the effects of medicines and may
have unusual reactions.
Acetaminophen and diphenhydramine is available over-the-counter under many brand names.
Ask your pharmacist any questions you have about this medication, especially if it is new to you.
Remember, keep this and all other medicines out of the reach of children, never share your
medicines with others, and use this medication only for the indication prescribed.
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up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive.
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The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions,
or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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